Choose the best topic sentence from the options below. Write the choice in the blank.

Choose the best topic sentence from the options below. Write the choice in the blank.

A.Who says smoking isn't dangerous?

B.How cigraette smoking increase one's chances of developing lung cancer.

C.Most medical doctors advise their patients not to smoke.

D.Cigarette smoking can lead to a number of serious health problems.

正确答案是D.